Lectin-dependent localization of cell surface sialic acid-binding lectin Siglec-9
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چکیده
منابع مشابه
Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamily.
The Siglecs are a recently discovered family of sialic acid-binding lectins of the immunoglobulin (Ig) superfamily. We report a molecule showing homology to the six first reported Siglecs, with the closest relationship to Siglec-3(CD33), Siglec-5, and Siglec-6(OBBP-1). The extracellular portion has two Ig-like domains, with the amino-terminal V-set Ig domain including amino acid residues known ...
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(cSBL) is known to have anti-tumor activity. cSBL is a multifunctional protein and is recognized as a pyrimidine basespecific ribonuclease. In respect to its ribonuclease activity, cSBL belongs to the RNase A superfamily, and is a very heat-stable enzyme. It retains 100% activity after heating at 100 °C for 5 min. Four RNases have been isolated from the Rana family of frogs, and their primary s...
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CD22 is a B cell-restricted glycoprotein involved in signal transduction and modulation of cellular activation. It is also an I-type lectin (now designated Siglec-2), whose extracellular domain can specifically recognize alpha2-6-linked sialic acid (Sia) residues. This activity is postulated to mediate intercellular adhesion and/or to act as a coreceptor in antigen-induced B cell activation. Ho...
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Amino acid residues 283-297 from sialic acid-binding immunoglobulin-like lectin 9 (Siglec-9) form a cyclic peptide ligand targeting vascular adhesion protein-1 (VAP-1). VAP-1 is associated with the transfer of leukocytes from blood to tissues upon inflammation. Therefore, analogs of Siglec-9 peptide are good candidates for visualizing inflammation non-invasively using positron emission tomograp...
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Sialic acid binding lectin (SBL) isolated from Rana catesbeiana oocytes is a multifunctional protein which has lectin activity, ribonuclease activity and antitumor activity. However, the mechanism of antitumor effects of SBL is unclear to date and the validity for human leukemia cells has not been fully studied. We report here that SBL shows cytotoxicity for some human leukemia cell lines inclu...
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ژورنال
عنوان ژورنال: Cytotechnology
سال: 2014
ISSN: 0920-9069,1573-0778
DOI: 10.1007/s10616-014-9691-6